Article
Human Telomerase Reverse Transcriptase Gene Promoter Mutation in Serum of Patients with Hepatocellular Carcinoma.
Oncology - 1 Jan 2020
Ako Soichiro, Nouso Kazuhiro, Kinugasa Hideaki, Matsushita Hiroshi, Terasawa Hiroyuki, Adachi Takuya, Wada Nozomu, Takeuchi Yasuto, Mandai Mari, Onishi Hideki, Ikeda Fusao, Shiraha Hidenori, Takaki Akinobu, Fujioka Shinichi, Mimura Tetsushige, Okada Hiroyuki
Abstract excerpt
BACKGROUND: Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evaluated the feasibility and prognostic value of hTERT promoter mutations identified in circulating...
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