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Article

Polygenic Risk and Exposure Severity Predict Trajectories of PTSD: A Prospective Cohort Study.

Molecular psychiatry - 1 Jan 2026

Mann Frank D, Waszczuk Monika A, Clouston Sean A P, Bromet Evelyn J, Marx Brian P, Shabalin Andrey A, Docherty Anna R, Kuan Pei-Fen, Carr Melissa A, Yang Xiaohua, Luft Benjamin J, Kotov Roman

Abstract excerpt

Posttraumatic stress disorder (PTSD) is persistent over time, thus identifying risk factors for chronic PTSD is crucial for clinical research. Trauma exposure severity and polygenic liability are two established predictors of PTSD onset and severity, but their contributions to the long-term course of PTSD remain largely unknown. In this prospective longitudinal cohort study, we tested whether severity of trauma...

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Identifiers

PMID: 40973784
DOI: 10.1038/s41380-025-03235-2
PMCID: PMC12927551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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