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Article

Polygenic risk associated with post-traumatic stress disorder onset and severity

7 Jun 2019

Abstract excerpt

Abstract Post-traumatic stress disorder (PTSD) is a psychiatric illness with a highly polygenic architecture without large effect-size common single-nucleotide polymorphisms (SNPs). Thus, to capture a substantial portion of the genetic contribution, effects from many variants need to be aggregated. We investigated various aspects of one such approach that has been successfully applied to many traits, polygenic...

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PMID: 31175274
DOI: 10.1038/s41398-019-0497-3

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