Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group.

doi:10.1200/JCO.2007.15.4245

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Article

Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2009

Büchner Thomas, Berdel Wolfgang E, Haferlach Claudia, Haferlach Torsten, Schnittger Susanne, Müller-Tidow Carsten, Braess Jan, Spiekermann Karsten, Kienast Joachim, Staib Peter, Grüneisen Andreas, Kern Wolfgang, Reichle Albrecht, Maschmeyer Georg, Aul Carlo, Lengfelder Eva, Sauerland Maria-Cristina, Heinecke Achim, Wörmann Bernhard, Hiddemann Wolfgang

Abstract excerpt

PURPOSE: The purpose of the study was to assess the contribution of age and disease variables to the outcome of untreated patients with acute myeloid leukemia (AML) receiving varying intensive induction chemotherapy. PATIENTS AND METHODS: Patients 16 to 85 years of age with primary AML, known karyotype, and uniform postremission chemotherapy enrolled onto two consecutive trials were eligible and were randomly...

Topics

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Male

Middle Aged

Multivariate Analysis

Mutation

Nuclear Proteins

Nucleophosmin

Prognosis

fms-Like Tyrosine Kinase 3

Source

Open in PubMed

Identifiers

PMID: 19047294
DOI: 10.1200/JCO.2007.15.4245

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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