Article
Age‐stratified machine learning identifies divergent prognostic significance of molecular alterations in AML
1 May 2025
Abstract excerpt
Abstract Risk stratification in acute myeloid leukemia (AML) is driven by genetics, yet patient age substantially influences therapeutic decisions. To evaluate how age alters the prognostic impact of genetic mutations, we pooled data from 3062 pediatric and adult AML patients from multiple cohorts. Signaling pathway mutations dominated in younger patients, while mutations in epigenetic regulators, spliceosome...
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