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Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.

Diabetes - 1 Dec 2025

Raghavan Sridharan, Litkowski Elizabeth, Jensen Aubrey, Charest Brian, Wang Zeyuan, Hui Qin, Chen Hua-Chang, Rhee Mary K, Leong Aaron, Meigs James B, Lange Leslie, Lange Ethan, Reaven Peter, Hung Adriana, Zhou Jin, Sun Yan V, Phillips Lawrence S

Abstract excerpt

Hypoglycemia is a preventable adverse treatment effect in diabetes patients, but genetic markers to identify those with increased susceptibility are lacking. We performed a case/control genome-wide association study (GWAS) of hypoglycemia in U.S. Million Veteran Program (MVP) participants with medication-treated diabetes. Case participants had an outpatient random serum/plasma glucose <70 mg/dL or an emergency...

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Identifiers

PMID: 40971195
DOI: 10.2337/db25-0304
PMCID: PMC12645173

Genes

MVP
SIX2
SIX3
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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