Article
Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA1c.
Scientific reports - 23 Nov 2017
Hachiya Tsuyoshi, Komaki Shohei, Hasegawa Yutaka, Ohmomo Hideki, Tanno Kozo, Hozawa Atsushi, Tamiya Gen, Yamamoto Masayuki, Ogasawara Kuniaki, Nakamura Motoyuki, Hitomi Jiro, Ishigaki Yasushi, Sasaki Makoto, Shimizu Atsushi
Abstract excerpt
Glycated haemoglobin (HbA1c) is widely used as a biomarker for the diagnosis of diabetes, for population-level screening, and for monitoring the glycaemic status during medical treatment. Although the heritability of HbA1c has been estimated at ~55-75%, a much smaller proportion of phenotypic variance is explained by the HbA1c-associated variants identified so far. To search for novel loci influencing the HbA1c...
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