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Article

APOE genotype and cognitive decline: educational context as a moderator of genetic risk.

The journals of gerontology. Series B, Psychological sciences and social sciences - 25 Jul 2025

Walsemann Katrina M, Jackson Heide M, Boardman Jason D, Herd Pamela

Abstract excerpt

OBJECTIVES: The apolipoprotein E (APOE) ε4 allele is linked to increased risk of Alzheimer's disease and cognitive decline. While educational attainment appears to mitigate this risk, it is not a direct measure of the early-life environment. This study examined whether childhood exposure to well- versus poorly resourced educational contexts modified the association between APOE ε4 and cognitive decline,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40580546
DOI: 10.1093/geronb/gbaf110
PMCID: PMC12296396

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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