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Article

Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation.

Journal of neurochemistry - 1 Sept 2025

Smith Ethan D, Torrellas Jose, McKenna Robert, Vo Quan, Mietzsch Mario, Borchelt David R, Prokop Stefan, Chakrabarty Paramita

Abstract excerpt

The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP) is largely uncharacterized. Towards this, we examined how acetylation mimicking or nullifying mutations on five sites of tau (K311,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40917003
DOI: 10.1111/jnc.70221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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