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Article

Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade

28 May 2020

Abstract excerpt

Abstract Mechanism-based strategies to overcome resistance to PD-1 blockade therapy are urgently needed. We developed genetic acquired resistant models of JAK1, JAK2, and B2M loss-of-function mutations by gene knockout in human and murine cell lines. Human melanoma cell lines with JAK1/2 knockout became insensitive to IFN-induced antitumor effects, while B2M knockout was no longer recognized by antigen-specific T...

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PMID: 32467343
DOI: 10.1158/2159-8290.cd-19-1409

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