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Article

ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis

4 Sept 2025

Abstract excerpt

Androgen receptor (AR)-mediated signaling is essential for PC tumorigenesis. In the TCGA database we observed a positive correlation between ECD and AR expression. Consistently, Dihydrotestosterone (DHT) treatment of PC cell lines increased ECD mRNA and protein levels, and AR knockdown (KD) reduced ECD expression. Bioinformatic analysis predicted three consensus androgen response elements in the ECD promoter, and...

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PMID: 40908313
DOI: 10.1038/s41388-025-03559-x

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