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Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta

8 Jul 2025

Abstract excerpt

Serotonin (5-hydroxytryptamine; 5-HT) is transported into the human placenta through the serotonin transporter (SERT/SLC6A4) on the surface of the syncytiotrophoblast. During this transit, a significant amount of 5-HT becomes concentrated in the cytotrophoblast nucleus. We used immunochemistry, inhibitors of SERT and transglutaminase 2, and RNA sequencing to elucidate the mechanism and consequences of this...

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PMID: 40898405
DOI: 10.1210/endocr/bqaf124

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