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Article

Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.

Journal of cellular physiology - 1 Dec 2017

Hadden Coedy, Fahmi Tariq, Cooper Anthonya, Savenka Alena V, Lupashin Vladimir V, Roberts Drucilla J, Maroteaux Luc, Hauguel-de Mouzon Sylvie, Kilic Fusun

Abstract excerpt

Serotonin (5-HT) and its specific transporter, SERT play important roles in pregnancy. Using placentas dissected from 18d gestational SERT-knock out (KO), peripheral 5-HT (TPH1)-KO, and wild-type (WT) mice, we explored the role of 5-HT and SERT in placental functions in detail. An abnormal thick band of fibrosis and necrosis under the giant cell layer in SERT-KO placentas appeared only moderately in TPH1-KO and...

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Source

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Identifiers

PMID: 28109119
DOI: 10.1002/jcp.25812
PMCID: PMC5522371

Genes

TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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