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Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit

23 Aug 2023

Abstract excerpt

BACKGROUND: Serotonin (5-HT) is a biogenic monoamine with diverse functions in multiple human organs and tissues. During pregnancy, tightly regulated levels of 5-HT in the fetoplacental unit are critical for proper placental functions, fetal development, and programming. Despite being a non-neuronal organ, the placenta expresses a suite of homeostatic proteins, membrane transporters and metabolizing enzymes, to...

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PMID: 37612712
DOI: 10.1186/s12958-023-01128-z

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