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Article

AEBP1 drives fibroblast-mediated T cell dysfunction in tumors

1 Sept 2025

Abstract excerpt

T cell dysfunction enables tumor immune evasion, understanding its mechanism is crucial for improving immunotherapy. Here we show, by RNA-sequencing analysis of human colon adenocarcinoma and triple-negative breast cancer tissues, that expression of Adipocyte Enhancer-Binding Protein 1 (AEBP1) positively correlates with T cell dysfunction and indicative of unfavorable patient outcomes. Subsequent single-cell RNA...

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PMID: 40890191
DOI: 10.1038/s41467-025-63659-w

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