Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus.

doi:10.1158/1078-0432.CCR-17-3103

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Article

Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018

Schrock Alexa B, Pavlick Dean, Klempner Samuel J, Chung Jon H, Forcier Brady, Welsh Allison, Young Lauren, Leyland-Jones Bryan, Bordoni Rodolfo, Carvajal Richard D, Chao Joseph, Kurzrock Razelle, Sicklick Jason K, Ross Jeffrey S, Stephens Philip J, Devoe Craig, Braiteh Fadi, Ali Siraj M, Miller Vincent A

Abstract excerpt

Purpose: Genomic profiling of tumor biopsies from advanced gastrointestinal and anal cancers is increasingly used to inform treatment. In some cases, tissue biopsy can be prohibitive, and we sought to investigate whether analysis of blood-derived circulating tumor DNA (ctDNA) may provide a minimally invasive alternative.Experimental Design: Hybrid capture-based genomic profiling of 62 genes was performed on...

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Identifiers

PMID: 29363525
DOI: 10.1158/1078-0432.CCR-17-3103
PMCID: PMC6076990

Genes

BRAF
EGFR
KRAS

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