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Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis

31 Aug 2025

Abstract excerpt

BACKGROUND: While several recent studies have documented the importance of efflux pumps as mediators of rifampin (RIF) resistance, it remains uncertain which efflux pumps play major roles in rifampin-resistant Mycobacterium tuberculosis strains harboring rpoB gene mutations. METHODS: In this study, minimum inhibitory concentration (MIC) values for RIF were calculated and the expression of 13 efflux pump genes was...

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PMID: 40887591
DOI: 10.1186/s12941-025-00816-5

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