Article
Evaluation of efflux pump gene expression among drug susceptible and drug resistant strains of Mycobacterium tuberculosis from Iran.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2015
Kardan Yamchi Jalil, Haeili Mehri, Gizaw Feyisa Seifu, Kazemian Hossein, Hashemi Shahraki Abdolrazagh, Zahednamazi Fatemeh, Imani Fooladi Abbas Ali, Feizabadi Mohammad Mehdi
Abstract excerpt
Absence of mutations within the genes encoding drug targets in some phenotypically drug resistant strains of Mycobacterium tuberculosis suggests possible involvement of alternative mechanisms such as over-expression of efflux pumps. We investigated the expression level of Rv1410c, Rv2459, Rv1218c and Rv1273c efflux pumps gene by real-time quantitative reverse transcription PCR (qRT-PCR) in 31 clinical isolates of...
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