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Article

Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates.

Antimicrobial agents and chemotherapy - 1 May 2012

Balganesh Meenakshi, Dinesh Neela, Sharma Sreevalli, Kuruppath Sanjana, Nair Anju V, Sharma Umender

Abstract excerpt

Active efflux of drugs mediated by efflux pumps that confer drug resistance is one of the mechanisms developed by bacteria to counter the adverse effects of antibiotics and chemicals. To understand these efflux mechanisms in Mycobacterium tuberculosis, we generated knockout (KO) mutants of four efflux pumps of the pathogen belonging to different classes. We measured the MICs and kill values of two different...

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Identifiers

PMID: 22314527
DOI: 10.1128/AAC.06003-11
PMCID: PMC3346595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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