Article
Isoniazid and verapamil modulatory activity and efflux pump gene expression in Mycobacterium tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jun 2020
de Souza J V P, Murase L S, Caleffi-Ferracioli K R, Palomo C T, de Lima Scodro R B, Siqueira V L D, Pavan F R, Cardoso R F
Abstract excerpt
INTRODUCTION: Resistance to first-line anti-tuberculosis drugs is a major concern in the treatment of the disease. New strategies, such as the use of efflux pump inhibitors (EPIs), are being investigated to improve the outcome of the treatment. Verapamil (VP), one such inhibitor, was shown to inhibit several efflux pump (EP) Mycobacterium tuberculosis proteins and demonstrate synergic activity with anti-TB...
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