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Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis

26 Feb 2020

Abstract excerpt

BACKGROUND: How the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be systematically identified. METHODS: A total of 696 UPGs (including E1, E2, E3, and deubiquitinases) were silenced by small interfering RNA (siRNA) library in NSCLC...

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PMID: 32114396
DOI: 10.1016/j.ebiom.2020.102689

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