Article
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
European journal of cancer (Oxford, England : 1990) - 1 Mar 2013
Pallante Pierlorenzo, Malapelle Umberto, Berlingieri Maria Teresa, Bellevicine Claudio, Sepe Romina, Federico Antonella, Rocco Danilo, Galgani Mario, Chiariotti Lorenzo, Sanchez-Cespedes Montserrat, Fusco Alfredo, Troncone Giancarlo
Abstract excerpt
INTRODUCTION: UbcH10 codes for the cancer related E2 Ubiquitin Conjugating Enzyme, an enzymatic molecule with a key role in the ubiquitin-proteasome pathway. Current studies have suggested a critical role of UbcH10 in a variety of malignancies, including human thyroid, breast, ovarian and colorectal carcinomas. The aim of this study has been to extend the analysis of UbcH10 expression to lung cancer. This...
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