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Enhancing the virulence of G2a subtype PEDV by chimeric expression of G2c subtype S gene.

Veterinary microbiology - 1 Nov 2025

Pan Shuonan, Zou Jingxian, Mou Chunxiao, Wang Zhisheng, Liu Huili, Fu Lizhi, Chen Zhenhai

Abstract excerpt

Among the various causes of pig diarrhea, porcine epidemic diarrhea (PED) remains a severe disease causing significant economic losses to the global swine industry. Given the rapid variation of the PEDV spike (S) protein, it is crucial to investigate how S protein of different genotypes influence the pathogenicity and immunogenicity of PEDV. Herein, chimeric PEDV strains were constructed by inserting the S gene...

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Identifiers

PMID: 40976147
DOI: 10.1016/j.vetmic.2025.110728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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