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Article

Spike gene variability in porcine epidemic diarrhea virus as a determinant for virulence.

Journal of virology - 18 Mar 2025

Li Wentao, Hangalapura Basav N, van den Elzen Paul, van den Born Erwin, van Kuppeveld Frank J M, Rottier Peter J M, Bosch Berend-Jan

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) is a pathogenic coronavirus that targets the swine intestinal tract, leading to acute diarrhea and high mortality in neonatal piglets. PEDV is categorized into different genotypes based on genetic variations, especially in the spike (S) gene. The S protein is crucial for viral entry and a major immune target. Significant differences in virulence have been observed among PEDV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40001283
DOI: 10.1128/jvi.02165-24
PMCID: PMC11915861

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