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Article

Changes in the motifs in the D0 and SD2 domains of the S protein drive the evolution of virulence in enteric coronavirus porcine epidemic diarrhea virus.

Journal of virology - 15 Apr 2025

Ma Zhiqian, Li Zhiwei, Li Yongqi, Zhao Xiaojing, Zheng Congsen, Li Yang, Guo Xuyang, Xu Lele, Zheng Zifang, Liu Guangliang, Zheng Haixue, Xiao Shuqi

Abstract excerpt

Since 2010, highly virulent mutant GII subtype porcine epidemic diarrhea virus (PEDV) strains derived from GI subtype strains have caused significant economic losses in the pig industry. However, the molecular mechanism of PEDV virulence evolution remains unclear. It has been predicted that, compared to the S proteins of GI strains, five N-linked glycosylation sites have changed in the highly virulent GII PEDV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 40035514
DOI: 10.1128/jvi.02092-24
PMCID: PMC11998522

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