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Article

Impact of scaffold material choice on osteosarcoma phenotype and drug responses in 3D.

Acta biomaterialia - 1 Oct 2025

Monette Callan E, Lee Jeehee, Peasah Abena, Sayles Leanne C, Tai Michelle, Sweet-Cordero E Alejandro, Yang Fan

Abstract excerpt

Biomaterials-based 3D models have emerged as new cancer research tools for studying osteosarcoma (OS). However, the impact of scaffold material choice on OS phenotype and drug responses in 3D remains largely unknown, as previous studies used different biomaterials as scaffolds without direct comparison. In this study, we systematically compared four biomaterials: Gelatin methacrylate (GelMA), Gelatin microribbons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40882907
DOI: 10.1016/j.actbio.2025.08.046
PMCID: PMC12919678

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