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Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells.

Advanced healthcare materials - 1 Dec 2016

Wang Kui, Kievit Forrest M, Erickson Ariane E, Silber John R, Ellenbogen Richard G, Zhang Miqin

Abstract excerpt

The lack of in vitro models that support the growth of glioblastoma (GBM) stem cells (GSCs) that underlie clinical aggressiveness hinders developing new, effective therapies for GBM. While orthotopic patient-derived xenograft models of GBM best reflect in vivo tumor behavior, establishing xenografts is a time consuming, costly, and frequently unsuccessful endeavor. To address these limitations, a 3D porous...

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Source

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Identifiers

PMID: 27805789
DOI: 10.1002/adhm.201600684
PMCID: PMC5253135

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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