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Article

Spatial tumour characteristics as an indirect marker of metabolic dysregulation: evaluation for non-invasive IDH-genotyping of glioma using hybrid [18 F]FET-PET/MRI.

European journal of nuclear medicine and molecular imaging - 1 Feb 2026

Lohmeier Johannes, Meinhardt Jenny, Radbruch Helena, Reyes Mauricio, Brenner Winfried, Tietze Anna, Makowski Marcus R

Abstract excerpt

PURPOSE: The isocitrate dehydrogenase (IDH) genotype is crucial for diagnosing and managing adult-type diffuse glioma. We investigated spatial tumour characteristics in treatment-naïve glioma using an U-Net-based CNN and evaluated associations with metabolic dysfunction and IDH genotype. METHODS: Between 2015 and 2024 patients with confirmed contrast-enhancing glioma were pre-operatively investigated using MRI or...

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Identifiers

PMID: 40866645
DOI: 10.1007/s00259-025-07520-8
PMCID: PMC12860868

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