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Integration of MRI radiomics and germline genetics to predict the IDH mutation status of gliomas

16 Jun 2025

Abstract excerpt

The molecular profiling of gliomas for isocitrate dehydrogenase ( IDH ) mutations currently relies on resected tumor samples, highlighting the need for non-invasive, preoperative biomarkers. We investigated the integration of glioma polygenic risk scores (PRS) and radiographic features for prediction of IDH mutation status. We used 256 radiomic features, a glioma PRS and demographic information in 158 glioma...

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PMID: 40523904
DOI: 10.1038/s41698-025-00980-z

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