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Article

Predictive IDH Genotyping Based on the Evaluation of Spatial Metabolic Heterogeneity by Compartmental Uptake Characteristics in Preoperative Glioma Using 18F-FET PET.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Nov 2023

Lohmeier Johannes, Radbruch Helena, Brenner Winfried, Hamm Bernd, Tietze Anna, Makowski Marcus R

Abstract excerpt

Molecular markers are of increasing importance for classifying, treating, and determining the prognosis for central nervous system tumors. Isocitrate dehydrogenase (IDH) is a critical regulator of glucose and amino acid metabolism. Our objective was to investigate metabolic reprogramming of glioma using compartmental uptake (CU) characteristics in O-(2-18F-fluoroethyl)-l-tyrosine (FET) PET and to evaluate its...

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Identifiers

PMID: 37652542
DOI: 10.2967/jnumed.123.265642
PMCID: PMC10626372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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