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Article

GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancer

24 Aug 2025

Abstract excerpt

Alterations in neurotransmitter signaling can influence colorectal cancer (CRC). In a large, randomized Phase III clinical trial (CALGB/SWOG 80405) involving patients with metastatic CRC, high expression of gamma-aminobutyric acid (GABA) pathway gene GAD1 and low expression of ABAT, indicative of a GABAergic environment, were associated with worse progression-free survival and overall survival outcomes. A...

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PMID: 40851030
DOI: 10.1038/s41388-025-03546-2

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