Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer

17 Jun 2024

Abstract excerpt

Abstract Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABAA and GABAB receptors have been implicated in contributing to the effects of GABA in colorectal cancer, with both pro‐ and anti‐tumorigenic functions identified. However, their subunit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Stress, Anesthesia, and Immune Response
Share to GABA and Rice Research
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38886975
DOI: 10.1002/prp2.1226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancerPMID 38886975Read ↗

GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancerSemantic proximity Read ↗

Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinomaSemantic proximity Read ↗

Therapeutically leveraging GABA A receptors in cancerSemantic proximity Read ↗

EphB6 deficiency in intestinal neurons promotes tumor growth in colorectal cancer by neurotransmitter GABA signalingSemantic proximity Read ↗

Enhanced expression of GABRD predicts poor prognosis in patients with colon adenocarcinomaSemantic proximity Read ↗

Multi-Omics Unveils Strain-Specific Neuroactive Metabolite Production Linked to Inflammation Modulation by <i>Bacteroides</i> and Their Extracellular VesiclesSemantic proximity Read ↗

GABA production and structure of gadB / gadC genes in Lactobacillus and Bifidobacterium strains from human microbiotaSemantic proximity Read ↗

Beyond Mutations: miR-101a as a Molecular Bridge Linking Ethanolamine, Microbial Dysbiosis, and Inflammation in Obesity-Driven Colorectal CancerSemantic proximity Read ↗

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter TryptamineSemantic proximity Read ↗

Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABASemantic proximity Read ↗

Adrenergic signaling induces a pro-tumorigenic B cell state in colorectal cancerSemantic proximity Read ↗

GABRD promotes progression and predicts poor prognosis in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.