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SFRP2 and RPRM as methylation based serum biomarkers for the detection of gastric cancer

24 Aug 2025

Abstract excerpt

BACKGROUND: Gastric cancer (GC) has a high mortality rate due to the diagnosis in advanced stages. Aberrant DNA methylation is the earliest event in carcinogenesis and can be noninvasively detected in cell-free DNA (cfDNA) from gastric cancer patients. METHODS: A total of 143 serum samples were analyzed, including 33 GC patients, 30 chronic gastritis (ChG) patients, and 80 healthy individuals. Additionally,...

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Share to Epigenetics and DNA Methylation
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PMID: 40849852
DOI: 10.1007/s12672-025-03472-5

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