Reverse control of biological networks to restore phenotype landscapes.

Abstract excerpt

Biological systems consist of genetic elements and their regulatory interactions, forming networks that maintain life. However, accumulated alterations such as DNA damage can distort biological behavior, leading to undesirable responses to stimulus. This raises the question of whether we can restore their nominal stimulus-response relationships. Current control approaches tend to enforce a single desired response...

Topics

• Phenotype
• Cells
• Signal Transduction
• Systems Biology
• Mathematics
• Animals
• Gene Regulatory Networks