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Article

Regulostat Inferelator: a novel network biology platform to uncover molecular devices that predetermine cellular response phenotypes.

Nucleic acids research - 22 Aug 2019

Ung Choong Yong, Ghanat Bari Mehrab, Zhang Cheng, Liang Jingjing, Correia Cristina, Li Hu

Abstract excerpt

With the emergence of genome editing technologies and synthetic biology, it is now possible to engineer genetic circuits driving a cell's phenotypic response to a stressor. However, capturing a continuous response, rather than simply a binary 'on' or 'off' response, remains a bioengineering challenge. No tools currently exist to identify gene candidates responsible for predetermining and fine-tuning cell response...

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PMID: 31114928
DOI: 10.1093/nar/gkz417
PMCID: PMC6698671

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