Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.

British journal of anaesthesia - 1 May 2019

Chang Leon, Daly Catherine, Miller Dorota M, Allen Paul D, Boyle John P, Hopkins Philip M, Shaw Marie-Anne

Abstract excerpt

BACKGROUND: Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics. Mitochondrial dysfunction has previously been associated with the MH-susceptible (MHS) phenotype in animal models, but evidence of this in human MH is limited. METHODS: We used high resolution respirometry to compare oxygen consumption rates (oxygen flux) between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics, Inhalation
Share to Electron Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Halothane

Share to Malignant Hyperthermia

Share to Mitochondria, Muscle

Share to Oxidative Phosphorylation

Share to Oxygen Consumption

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 30916033
DOI: 10.1016/j.bja.2019.02.010
PMCID: PMC6972232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.PMID 30916033Read ↗

Mitochondrial bioenergetics and intracellular calcium concentration in primary myotubes from mouse models of malignant hyperthermia.Semantic proximity Read ↗

Metabolic phenotype of skeletal muscle in early critical illness.Semantic proximity Read ↗

Decreased Mitochondrial Bioenergetics and Function Define a Distinct Metabolic Phenotype in Healthy Sedentary Individuals Detectable Through Non-Invasive CPETSemantic proximity Read ↗

Analysis of histomorphology in malignant hyperthermia-susceptible patients.Semantic proximity Read ↗

Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.Semantic proximity Read ↗

Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.Semantic proximity Read ↗

Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.Semantic proximity Read ↗

In Vivo and Ex Vivo Mitochondrial Function in COVID-19 Patients on the Intensive Care UnitSemantic proximity Read ↗

Photoacoustic imaging in mitochondrial diseaseSemantic proximity Read ↗

Skeletal muscle microalterations in patients carrying Malignant Hyperthermia-related mutations of the e-c coupling machinerySemantic proximity Read ↗

Mitochondrial function, fibre types and ageing: new insights from human muscle in vivoSemantic proximity Read ↗

Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.