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HER2 alterations across solid tumors: implications for comprehensive testing

16 Aug 2025

Abstract excerpt

PURPOSE: ERBB2 (HER2) alterations (eg, overexpression, amplification, and mutations) are known to drive tumor progression. These changes, particularly in non-breast and gastric/gastroesophageal cancers, remain poorly characterized. With pan-tumor approval of HER2-targeted therapies like Trastuzumab deruxetecan (T-DXd), understanding ERBB2 alterations across diverse cancers is crucial. METHODS: HER2 analysis was...

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PMID: 40828885
DOI: 10.1093/oncolo/oyaf258

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