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Article

ERBB2/HER2 landscape and prognostic impact: large-scale, real-world analysis across solid cancers.

ESMO open - 1 Jul 2026

Shreenivas A, Elliott A, Corbiere T, Chen H-Z, George B, Kamgar M, Chakrabarti S, Desai A, Bracken-Clarke D, Xue E, Floudas C S, Thomas J, Xiu J, Sledge G, Antonarakis E S, Boumber Y, Kurzrock R

Abstract excerpt

BACKGROUND: We evaluated the frequency and prognostic impact of human epidermal growth factor receptor 2 (HER2) protein expression [immunohistochemistry (IHC)] and correlations with ERBB2 genomic alterations in a large database of molecularly profiled real-world patients (Caris Life Sciences, Phoenix, AZ). MATERIALS AND METHODS: We analyzed 206 750 tumors for ERBB2 copy number alterations and pathogenic mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42296698
DOI: 10.1016/j.esmoop.2026.107772
PMCID: PMC13285824

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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