Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification

Abstract excerpt

Staphylococcus epidermidis is a major cause of hospital-acquired infections, especially those related to implanted medical devices. Understanding how S. epidermidis causes disease and devising ways to combat these infections have been hindered by an inability to genetically manipulate clinically significant hospital-adapted strains. Here, we provide the first comprehensive analyses of the barriers to the uptake...

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