Article
Genomic Signatures of Experimental Adaptation to Antimicrobial Peptides in Staphylococcus aureus.
G3 (Bethesda, Md.) - 1 Jun 2016
Johnston Paul R, Dobson Adam J, Rolff Jens
Abstract excerpt
The evolution of resistance against antimicrobial peptides has long been considered unlikely due to their mechanism of action, yet experimental selection with antimicrobial peptides (AMPs) results in rapid evolution of resistance in several species of bacteria. Although numerous studies have utilized mutant screens to identify loci that determine AMP susceptibility, there is a dearth of data concerning the...
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