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Optimization of the monoclonal antibody 3E1 through W32I mutation enhances antiviral efficacy against influenza virus subtypes H1N1 and H3N2.

Antiviral research - 1 Oct 2025

Guan Shanshan, Wang Qingyu, Nie Jiaojiao, Yao Xin, Xie Kunpeng, Zhao Weihao, Chang Yaotian, Zhu Lvzhou, Hui Jiaru, Yin Tieyan, Liu Xiaopan, Zhang Yingxin, Shan Yaming

Abstract excerpt

The influenza virus has caused a global pandemic with significant morbidity and mortality, underscoring the need to optimize antibodies for improved antiviral efficacy. The monoclonal antibody 3E1 effectively neutralizes Group 1 influenza subtypes, H1 and H5, by inhibiting acid-induced conformational changes of hemagglutinin (HA). However, its neutralizing activity is relatively weak against the Group 2 subtype,...

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Share to Antibodies, Neutralizing
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H1N1 Subtype

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PMID: 40818491
DOI: 10.1016/j.antiviral.2025.106260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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