Article
Complex interaction of δ-globin variant HbA2-Famagusta combined with β-globin variant Hb Monroe in cis with the HBB:c.-92C>G mutation: hematological characteristics and molecular diagnostic insights.
Expert review of hematology - 1 Dec 2025
Panyasai Sitthichai, Srisuwan Wibhasiri, Sumphanapai Thitima, Satthakarn Surada
Abstract excerpt
BACKGROUND: Hemoglobin (Hb) variants can cause clinical conditions like thalassemia. Understanding their molecular phenotypes and clinical profiles is essential for accurate diagnosis and genetic counseling. RESEARCH DESIGN AND METHODS: Blood samples from a 67-year-old Thai female and four relatives were analyzed using HPLC and capillary electrophoresis. PCR techniques and sequencing were used to identify globin...
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