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Article

δ-Hemoglobinopathies in Thailand: screening, molecular basis, genotype-phenotype interaction, and implication for prevention and control of thalassemia.

Annals of hematology - 1 Aug 2021

Singha Kritsada, Fucharoen Goonnapa, Fucharoen Supan

Abstract excerpt

The δ-globin gene defects are clinically silent but interaction with β-thalassemia can lead to a misdiagnosis of β-thalassemia carrier. We report an extensive molecular characterization of δ-hemoglobinopathies in Thailand. Study was done on 32,108 subjects, encountered at the thalassemia screening. Six different approaches based on the reduced Hb A2 or appearance of Hb A2-derivative were established for selective...

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PMID: 33834283
DOI: 10.1007/s00277-021-04510-2

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