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Article

Molecular understanding of unusual HbE-β+-thalassemia with Hb phenotype similar to HbE heterozygote: simple and rapid differentiation using HbE levels.

Annals of medicine - 1 Jan 2023

Jomoui Wittaya, Satthakarn Surada, Panyasai Sitthichai

Abstract excerpt

BACKGROUND: Low HbF expression in HbE-β+-thalassemia may lead to misdiagnosis of HbE heterozygosity. We aimed to characterize the β- and α-globin genes and the modifying factors related to HbF expression in patients with an Hb phenotype similar to that of HbE heterozygotes. Furthermore, screening tools for differentiating HbE-β+-thalassemia from HbE heterozygotes have been investigated. PARTICIPANTS AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37816374
DOI: 10.1080/07853890.2023.2267054
PMCID: PMC10732225

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