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Article

Elevated Hemoglobin A2: A Molecular Revisited, and Implications to β-Thalassemia Screening.

Journal of clinical laboratory analysis - 1 Aug 2026

Singha Kritsada, Pansuwan Anupong, Srivorakun Hataichanok, Chaibunruang Attawut, Yamsri Supawadee, Tepakhan Wanicha, Sanchaisuriya Kanokwan, Fucharoen Goonnapa, Fucharoen Supan

Abstract excerpt

BACKGROUND: In Thailand, the Hb A2 cut-off value for β-thalassemia carrier has been changed from 4.0% to 3.6% since 2015. We examined the molecular basis of β-thalassemia in a large cohort of Thai subjects with this change. METHODS: A total of 36,313 retrospective specimens encountered during January 2016 to June 2025 were reviewed, and 5909 subjects (16.7%) with Hb A2 ≥ 3.6% were recruited. Diagnosis of...

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PMID: 42357941
DOI: 10.1002/jcla.70294
PMCID: PMC13399722

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