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Article

Pore-C sequencing identifies episome-driven chromosome conformation perturbations differentiating pneumococcal epigenetic variants.

PLoS pathogens - 1 Aug 2025

Lim Tze Yee, Horsfield Samuel T, Troman Catherine M, Bentley Stephen D, Kwun Min Jung, Croucher Nicholas J

Abstract excerpt

Streptococcus pneumoniae (pneumococcus) is a genetically diverse opportunistic bacterial pathogen that expresses two phase-variable loci encoding restriction-modification systems. Comparisons of two genetically-distinct pairs of epigenetically-distinct variants, each distinguished by a stabilised arrangement of one of these phase-variable loci, found the consequent changes in genome-wide DNA methylation patterns...

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Topics

Streptococcus pneumoniae
Chromosomes, Bacterial
Epigenesis, Genetic
Plasmids
Genome, Bacterial
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Variation

DNA Copy Number Variations

Source

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Identifiers

PMID: 40811750
DOI: 10.1371/journal.ppat.1013392
PMCID: PMC12416852

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