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Article

Two Birds With One Stone: The Protective Role of the Antidiabetic Drug Sodium-Glucose Cotransporter-2 Inhibitor in Neurodegenerative Diseases.

The European journal of neuroscience - 1 Aug 2025

Zhang LiRong, Cai Liangchun, Lin Huiting, Wu Wenhua, Zhu Yixiao, Cai Jiaqin, Hu Congting, Lin Xinmiao, Sun Hong, Wei XiaoXia

Abstract excerpt

The neuroprotective role of sodium-glucose cotransporter-2 inhibitor (SGLT2i) has attracted considerable interest. The purpose of this study was to investigate the role of SGLT2i in several common neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Utilizing drug-target Mendelian randomization (MR) and...

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Identifiers

PMID: 40808471
DOI: 10.1111/ejn.70221

Genes

SLC5A2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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