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Article

The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth.

The Journal of cell biology - 6 Oct 2025

Caballero Daniel, Sutter Benjamin M, Xing Zheng, Wang Caroline, Choo Emma, Wang Yun, Yang Yu-San, Ghaemmaghami Sina, Lemoff Andrew, Tu Benjamin P

Abstract excerpt

An amino acid polymorphism in the Rad2/XPG protein Mkt1 (Mkt1-G30D) reportedly underlies variation in mitochondrial phenotypes among laboratory yeast, but the function of Mkt1 and the effects of the polymorphism are unknown. We confirm with genetics and biochemical assays guided by AlphaFold structure predictions that Mkt1 forms a complex with Pbp1, a messenger RNP protein that supports adaptations to respiratory...

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Identifiers

PMID: 40801888
DOI: 10.1083/jcb.202411169
PMCID: PMC12345631

Genes

HAP1

Variants

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