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Article

Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases.

Genes and immunity - 1 Apr 2025

Pandey Janardan P, Nietert Paul J, Namboodiri Aryan M, Kimball Christine, Flume Patrick A

Abstract excerpt

Immunoglobulin GM (γ marker) and KM (κ marker) allotypes-encoded by immunoglobulin heavy chain G (IGHG) and immunoglobulin κ constant (IGKC) genes-have been shown to be associated with immune responsiveness to a variety of self and nonself antigens. The aim of the present investigation was to determine whether allelic variation at the GM and KM loci was associated with antibody responsiveness to...

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Identifiers

PMID: 39774260
DOI: 10.1038/s41435-024-00318-y
PMCID: PMC12006017

Genes

FCGR2A

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