Article
Chlamydia trachomatis diversity viewed as a tissue-specific coevolutionary arms race.
Genome biology - 23 Oct 2008
Nunes Alexandra, Nogueira Paulo J, Borrego Maria J, Gomes João P
Abstract excerpt
BACKGROUND: The genomes of pathogens are thought to have evolved under selective pressure provided by the host in a coevolutionary arms race (the 'Red Queen's Hypothesis'). Traditionally, adaptation by pathogens is thought to rely not on whole chromosome dynamics but on gain/loss of specific genes, yielding differential abilities to infect distinct tissues. Thus, it is not known whether distinct host organs...
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